Document Detail

Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung function impairment in rabbits.
MedLine Citation:
PMID:  16125476     Owner:  NLM     Status:  MEDLINE    
We investigated whether end-expiratory lung volume (EELV) or lung mechanical parameters are more sensitive for the detection of a compromised gas exchange during bronchoconstriction and after surfactant depletion. EELV was determined via SF(6) multiple breath wash-outs in mechanically ventilated rabbits while a positive end-expiratory pressure (PEEP) of 1, 3 or 7 cm H(2)O was maintained. Airway resistance (R(aw)) and parenchymal elastance (H) were estimated from the pulmonary input impedance measured at each PEEP level by means of forced oscillations. Measurements were repeated during i.v. methacholine (MCh) infusions and following lung injury induced by saline lavage. MCh induced marked elevations in R(aw), with no significant change in EELV or H at any PEEP. After lavage, the severity of hypoxia was reflected systematically in significant decreases in EELV at all PEEP levels (-42+/-13%, -26+/-4%, and -18+/-5% at 1, 3 and 7 cm H(2)O, respectively), whereas compromised gas exchange was not associated with consistent changes in the mechanical parameters at a PEEP of 7 cm H(2)O (20+/-9% and 14+/-9% in R(aw) and H, respectively; p=0.2). We conclude that R(aw) is the only sensitive indicator for the detection of a compromised lung function during MCh infusions, whereas the estimation of EELV is necessary to follow the progression of a lung injury when a high PEEP level is applied.
Walid Habre; Pietro Scalfaro; Nathalie Schütz; Pascal Stucki; Ferenc Peták
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-24
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  152     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  72-82     Citation Subset:  IM    
Pediatric Anesthesia Unit, Geneva Children's Hospital, Switzerland.
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MeSH Terms
Airway Resistance / drug effects,  physiology
Analysis of Variance
Bronchoconstrictor Agents / pharmacology
Lung Compliance / drug effects,  physiology
Lung Diseases / diagnosis,  physiopathology*
Lung Volume Measurements / methods*
Methacholine Chloride / pharmacology
Positive-Pressure Respiration*
Pulmonary Gas Exchange / drug effects,  physiology
Respiratory Function Tests / methods*
Respiratory Mechanics / drug effects,  physiology*
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride

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