Document Detail

Measuring cardiac output during dobutamine infusion after off-pump coronary artery bypass: comparison of transesophageal echo-Doppler and thermodilution.
MedLine Citation:
PMID:  12476476     Owner:  NLM     Status:  MEDLINE    
AIM: To compare transesophageal echo-Doppler with thermodilution method for measuring cardiac output during dobutamine infusion after off-pump coronary artery bypass. METHOD: Using transesophageal echo-Doppler and thermodilution methods, we measured cardiac output in 30 patients after off-pump coronary artery bypass, immediately before and 5, 15, and 30 min after the introduction of continuous dobutamine infusion (3 microg/kg/min). Paired t-test and Bland-Altman analysis were used to compare the results obtained by two methods in this prospective study. RESULTS: Significant increase in cardiac output during dobutamine infusion was detected by both thermodilution (from 3.9 +/- 1.0 to 4.6 +/- 1.1 L/min; p < 0.001) and transesophageal echo-Doppler (from 3.8 +/- 1.2 to 4.8 +/- 1.4 L/min; p < 0.001). Initial measurement results of thermodilution and transesophageal echo-Doppler techniques showed clinically acceptable agreement, with a mean difference of only + 0.09 L/min (95% confidence interval (CI), 0.42 to + 0.61). Subsequently repeated measurements after 5, 15, and 30 min showed almost the same agreement between the methods. The highest mean difference between the initial and repeated measurements was found at 5 min after the introduction of dobutamine infusion (-0.29 L/min, 95% CI, -1.06 to + 0.48). CONCLUSION: Transesophageal echo-Doppler and thermodilution can be interchangeable as methods for measuring cardiac output after off-pump coronary artery bypass.
Ino Husedzinović; Stjepan Barisin; Dinko Tonković; Sinisa Sostarić
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Croatian medical journal     Volume:  43     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  680-4     Citation Subset:  IM    
Department of Anesthesiology and Intensive Therapy, Dubrava University Hospital, Zagreb, Croatia.
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MeSH Terms
Cardiotonic Agents / administration & dosage*
Coronary Artery Bypass / methods*
Coronary Artery Disease / physiopathology,  surgery*
Dobutamine / administration & dosage*
Echocardiography, Transesophageal*
Heart Function Tests / methods*
Middle Aged
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

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