| Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus. | |
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MedLine Citation:
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PMID: 20493284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity. |
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Authors:
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Marzia M Giuliani; Alessia Biolchi; Davide Serruto; Francesca Ferlicca; Kay Vienken; Philipp Oster; Rino Rappuoli; Mariagrazia Pizza; John Donnelly |
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Publication Detail:
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Type: Journal Article Date: 2010-05-21 |
Journal Detail:
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Title: Vaccine Volume: 28 ISSN: 1873-2518 ISO Abbreviation: Vaccine Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: 5023-30 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Bacterial / immunology* Blood Bactericidal Activity Complement System Proteins / immunology Female Humans Meningococcal Infections / immunology*, prevention & control Meningococcal Vaccines / immunology* Mice Neisseria meningitidis, Serogroup B / classification, immunology* Vaccines, Synthetic / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Meningococcal Vaccines; 0/Vaccines, Synthetic; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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