Document Detail


Measures of blood pressure and cognition in dialysis patients.
MedLine Citation:
PMID:  22716218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are few reports on the relationship of blood pressure with cognitive function in maintenance dialysis patients. The Cognition and Dialysis Study is an ongoing investigation of cognitive function and its risk factors in six Boston area hemodialysis units. In this analysis, we evaluated the relationship between different domains of cognitive function with systolic and diastolic blood pressure, pulse pressure, and intradialytic changes in systolic blood pressure, using univariate and multivariable linear regression models adjusted for age, sex, race, education, and primary cause of end-stage renal disease. Among 314 participants, mean age was 63 years; 47% were female, 22% were African American, and 48% had diabetes. The mean (SD) of systolic blood pressure, diastolic blood pressure, pulse pressure, and intradialytic change in systolic blood pressure were 141 (21), 73 (12), 68 (15), and -10 (24) mmHg, respectively. In univariate analyses, the performance on cognitive tests primarily assessing executive function and processing speeds was worse among participants with lower diastolic blood pressure and higher pulse pressure. These relationships were not statistically significant, however, in multivariable analyses. There was no association between cognitive function and systolic blood pressure or intradialytic change in systolic blood pressure in either univariate or multivariable analyses. We found no association between different measures of blood pressure and cognitive function in cross-sectional analysis. Longitudinal studies are needed to confirm these results.
Authors:
Lena M Giang; Hocine Tighiouart; Kristina V Lou; Brian Agganis; David A Drew; Kamran Shaffi; Tammy Scott; Daniel E Weiner; Mark J Sarnak
Related Documents :
16595908 - Combined effects of benidipine and diltiazem on cardiohemodynamics in anesthetized dogs.
22386348 - Epinephrine, vasopressin, and nitroglycerin improve neurologic outcome in porcine asphy...
624318 - Hemodynamic factors associated with the production of pain in angina pectoris.
22275528 - Ambient particulate matter and the response to orthostatic challenge in the elderly: th...
17003898 - High pressure solid state chemistry of carbon dioxide.
7666218 - Intracranial pressure changes induced during papaverine infusion for treatment of vasos...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-20
Journal Detail:
Title:  Hemodialysis international. International Symposium on Home Hemodialysis     Volume:  17     ISSN:  1542-4758     ISO Abbreviation:  Hemodial Int     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-09-25     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101093910     Medline TA:  Hemodial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  24-31     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Hemodialysis International © 2012 International Society for Hemodialysis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Boston
Cognition / physiology*
Female
Humans
Hypertension / psychology
Male
Middle Aged
Renal Dialysis / psychology*
Risk Factors
Grant Support
ID/Acronym/Agency:
K23 DK071636/DK/NIDDK NIH HHS; K23 DK071636/DK/NIDDK NIH HHS; K24 DK078204/DK/NIDDK NIH HHS; K24 DK078204/DK/NIDDK NIH HHS; R01 DK078204/DK/NIDDK NIH HHS; R21 DK068310/DK/NIDDK NIH HHS; R21 DK068310/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Isolation and characterization of bovine parainfluenza virus type 3 from water buffaloes (Bubalus bu...
Next Document:  Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Frami...