Document Detail

Measurements of water content in hydroxypropyl-methyl-cellulose based hydrogels via texture analysis.
MedLine Citation:
PMID:  23218365     Owner:  NLM     Status:  In-Data-Review    
In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in the needle compression test. The work of penetration was successfully related to the hydrogel water content, assayed by a gravimetric technique. Moreover, a fitting model was proposed to correlate the two variables (the water content and the work of penetration). The availability of a reliable tool is useful both in the quantification of the water uptake phenomena, both in the management of the testing processes of novel pharmaceutical solid dosage forms.
Gaetano Lamberti; Sara Cascone; Maria Margherita Cafaro; Giuseppe Titomanlio; Matteo d'Amore; Anna Angela Barba
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Publication Detail:
Type:  Journal Article     Date:  2012-10-08
Journal Detail:
Title:  Carbohydrate polymers     Volume:  92     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  765-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Dipartimento di Ingegneria Industriale (DIIn), Università di Salerno, Via Ponte don Melillo, Italy. Electronic address:
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