Document Detail


Measurements of red blood cell methotrexate concentrations and lymphocyte subsets during therapy of rheumatoid arthritis.
MedLine Citation:
PMID:  3978894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine patients with rheumatoid arthritis were treated with low dose oral weekly methotrexate for 6 months. Successful therapy was not associated with changes in concentrations of total circulating lymphocytes nor with alterations of T lymphocytes in the helper-inducer, OKT4, or cytotoxic-suppressor, OKT8, subpopulations. Concentrations of methotrexate in circulating erythrocytes stabilized by 1 month of therapy and this measurement did not correlate with clinical efficacy or methotrexate toxicity in the long-term patient assessments.
Authors:
S Duby; J Karsh; J F Prchal; V M Whitehead; C K Osterland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  3     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1985 Jan-Mar
Date Detail:
Created Date:  1985-05-14     Completed Date:  1985-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arthritis, Rheumatoid / blood,  drug therapy*,  pathology,  physiopathology
Drug Evaluation
Erythrocytes / metabolism*
Female
Humans
Lymphocytes / classification*
Male
Methotrexate / adverse effects,  blood*,  therapeutic use
Middle Aged
Osmolar Concentration
Chemical
Reg. No./Substance:
59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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