Document Detail

Measurements of oxygen tension from the canine gastric mucosa under the influence of vasoactive and acid stimulating agents and following vagotomy. Implications on the pathophysiology of peptic ulceration.
MedLine Citation:
PMID:  997688     Owner:  NLM     Status:  MEDLINE    
By the use of a multiwire platinum electrode mucosal tissue pO2 from the canine gastric antrum is continuously recorded. Injection of norepinephrine causes a short, steep fall of mucosal pO2, naftidrofuryl elevates mucosal pO2 for several minutes in spite of reduced arterial blood pressure, pentagastrin produces a biphasic response, a temporary rise of mucosal pO2 is followed by a longer lasting decrease, vagotomy causes a considerable and more persistent drop of mucosal pO2. These experimental findings are discussed in their possible relations to the clinical problem of ulcer formation and therapy of gastroduodenal bleeding.
M M Linder; P Alken; R Muschaweck; W Hartel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für experimentelle Chirurgie     Volume:  9     ISSN:  0323-5580     ISO Abbreviation:  Z Exp Chir     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0154510     Medline TA:  Z Exp Chir     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Furans / pharmacology*
Gastric Mucosa / physiopathology*
Nafronyl / pharmacology*
Norepinephrine / pharmacology*
Oxygen Consumption / drug effects*
Pentagastrin / pharmacology*
Peptic Ulcer / etiology,  physiopathology*
Postoperative Complications / physiopathology
Reg. No./Substance:
0/Furans; 31329-57-4/Nafronyl; 51-41-2/Norepinephrine; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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