| Measurements of oxygen tension from the canine gastric mucosa under the influence of vasoactive and acid stimulating agents and following vagotomy. Implications on the pathophysiology of peptic ulceration. | |
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MedLine Citation:
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PMID: 997688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By the use of a multiwire platinum electrode mucosal tissue pO2 from the canine gastric antrum is continuously recorded. Injection of norepinephrine causes a short, steep fall of mucosal pO2, naftidrofuryl elevates mucosal pO2 for several minutes in spite of reduced arterial blood pressure, pentagastrin produces a biphasic response, a temporary rise of mucosal pO2 is followed by a longer lasting decrease, vagotomy causes a considerable and more persistent drop of mucosal pO2. These experimental findings are discussed in their possible relations to the clinical problem of ulcer formation and therapy of gastroduodenal bleeding. |
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Authors:
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M M Linder; P Alken; R Muschaweck; W Hartel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zeitschrift für experimentelle Chirurgie Volume: 9 ISSN: 0323-5580 ISO Abbreviation: Z Exp Chir Publication Date: 1976 |
Date Detail:
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Created Date: 1977-01-25 Completed Date: 1977-01-25 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0154510 Medline TA: Z Exp Chir Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 239-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Dogs Female Furans / pharmacology* Gastric Mucosa / physiopathology* Male Nafronyl / pharmacology* Norepinephrine / pharmacology* Oxygen Consumption / drug effects* Pentagastrin / pharmacology* Peptic Ulcer / etiology, physiopathology* Postoperative Complications / physiopathology Vagotomy* |
| Chemical | |
Reg. No./Substance:
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0/Furans; 31329-57-4/Nafronyl; 51-41-2/Norepinephrine; 5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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