| Measurements of optical pathlength using phase-resolved spectroscopy in patients undergoing cardiopulmonary bypass. | |
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MedLine Citation:
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PMID: 17242091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Near infrared spectroscopy (NIRS) has been used during cardiac surgery to monitor cerebral oxygenation although the validity of this technique has yet to be established. Although optical pathlength included in the algorithm for calculating NIRS values is supposed to be constant, recent evidence has suggested that optical pathlength could be affected by acute hemodilution in animals. We conducted the present study to investigate whether optical pathlength changes during cardiopulmonary bypass (CPB), and whether these changes affect NIRS values in adult patients. METHODS: Nine patients undergoing elective cardiac surgery with CPB were enrolled in this study. Optical pathlength and cerebral NIRS values (oxyhemoglobin [DeltaO(2)Hb] and tissue oxygen index) were measured by phase-resolved spectroscopy and NIRO 100, respectively. Optical pathlength, hemoglobin concentration, and NIRS values were measured at the following points: 1) after the induction of anesthesia, 2) 10 min after the start of CPB, 3) 60 min after the start of CPB, and 4) 1 h after CPB. The associations between optical pathlength and other variables were analyzed by Pearson correlation coefficients and multiple regression analysis. RESULTS: Optical pathlength significantly increased starting at 27.7-30.8 cm at 10 min, and 31.3 cm at 60 min after the start of CPB (P < 0.0001). Hemoglobin concentrations significantly decreased (from 11.2 to 7.1 g/dL at 10 min and 7.7 g/dL at 60 min P < 0.0001). There was a significant correlation (r = 0.55, P < 0.001) between percentage changes in pathlength and hemoglobin concentration. Multiple regression analysis showed that optical pathlength was a significant determinant of DeltaO2Hb. CONCLUSION: The results indicate that optical pathlength can change during CPB and its changes may affect DeltaO2Hb. |
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Authors:
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Kenji Yoshitani; Masahiko Kawaguchi; Takashi Okuno; Tomoko Kanoda; Yoshihiko Ohnishi; Masakazu Kuro; Mitsunori Nishizawa |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 104 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-23 Completed Date: 2007-03-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 341-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, National Cardiovascular Center, Suita, Osaka, Japan. kenji.yoshitani@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiopulmonary Bypass* Humans Middle Aged Optics and Photonics* / instrumentation Oxyhemoglobins / analysis, metabolism Spectroscopy, Near-Infrared / instrumentation, methods* |
| Chemical | |
Reg. No./Substance:
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0/Oxyhemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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