Document Detail

Measurements of myocardial metabolism in patients with ischemic heart disease.
MedLine Citation:
PMID:  9737488     Owner:  NLM     Status:  MEDLINE    
Therapeutic approaches to left ventricular dysfunction in ischemic heart disease are likely to be guided by the answers to 2 major questions: (1) which mechanisms account for the deterioration or loss of contractile function, and (2) can contractile function be improved or restored therapeutically? Both questions can face considerable diagnostic challenges. Two main mechanisms have been implicated in the pathophysiology of reversible dysfunction-myocardial hibernation and myocardial stunning. Both general concepts share a number of clinical features so that standard clinical approaches often fail to discriminate between them. The presence of regionally increased fibrosis in scar tissue formation associated with decreased blood flow further complicates the search for truly reversible dysfunction.
H R Schelbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  82     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-28     Completed Date:  1998-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61K-67K     Citation Subset:  AIM; IM    
Department of Molecular and Medical Pharmacology, University of California-Los Angeles School of Medicine, 90095-1735, USA.
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MeSH Terms
Blood Flow Velocity
Coronary Circulation
Energy Metabolism*
Myocardial Contraction
Myocardial Ischemia / metabolism*,  physiopathology,  radionuclide imaging
Myocardium / metabolism*
Ventricular Dysfunction, Left / metabolism,  physiopathology,  radionuclide imaging
Grant Support

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