| Measurements of myocardial metabolism in patients with ischemic heart disease. | |
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MedLine Citation:
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PMID: 9737488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Therapeutic approaches to left ventricular dysfunction in ischemic heart disease are likely to be guided by the answers to 2 major questions: (1) which mechanisms account for the deterioration or loss of contractile function, and (2) can contractile function be improved or restored therapeutically? Both questions can face considerable diagnostic challenges. Two main mechanisms have been implicated in the pathophysiology of reversible dysfunction-myocardial hibernation and myocardial stunning. Both general concepts share a number of clinical features so that standard clinical approaches often fail to discriminate between them. The presence of regionally increased fibrosis in scar tissue formation associated with decreased blood flow further complicates the search for truly reversible dysfunction. |
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Authors:
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H R Schelbert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: The American journal of cardiology Volume: 82 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-09-28 Completed Date: 1998-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 61K-67K Citation Subset: AIM; IM |
Affiliation:
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Department of Molecular and Medical Pharmacology, University of California-Los Angeles School of Medicine, 90095-1735, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Coronary Circulation Energy Metabolism* Humans Myocardial Contraction Myocardial Ischemia / metabolism*, physiopathology, radionuclide imaging Myocardium / metabolism* Prognosis Ventricular Dysfunction, Left / metabolism, physiopathology, radionuclide imaging |
| Grant Support | |
ID/Acronym/Agency:
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HL 29845/HL/NHLBI NIH HHS; HL 33177/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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