Document Detail


Measurements and mapping of 282,420 nerve fibers in the S1-5 nerve roots.
MedLine Citation:
PMID:  19769506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The study aims to analyze nerve fiber types in the sacral nerve roots as a prerequisite for stimulation. METHODS: One-micrometer cross-sections of human ventral and dorsal S1-5 roots were stained with osmium and toluidine blue. The total fiber diameter and myelin sheath were measured in 282,420 nerve fibers. RESULTS: The analysis revealed the following 3 main nerve fiber types: Aalpha fibers (diameter 6-14 microm), Agamma fibers (diameter 2-4 microm), and B fibers (diameter < 2 microm). The B fibers were absent in S-1, present in some S-2 fascicles, and abundant from S-3 to S-5. The Aalpha fibers dominated the S-1 roots and most fascicles of S-2 roots. In the S3-5 roots, only a few Aalpha fibers were present. The relative occurrence of Agamma fibers increased from S-1 to S-5. In dorsal roots, Agamma fibers represented approximately 70% of all nerve fibers in every root and fascicle. CONCLUSIONS: The B fibers represented efferent parasympathetic fibers. These fibers were concentrated in certain areas of the nerve roots, not randomly distributed. The Aalpha fibers innervate lower-extremity muscles and sphincters. The inverse correlation of Aalpha and Agamma fibers in the ventral roots from S-1 to S-5 is surprising. In dorsal roots, Agamma fibers may conduct pain, touch, and temperature signals. Highly selective fiber stimulation specific for type, location, and direction may improve sacral nerve stimulation for a spastic bladder in paraplegic individuals.
Authors:
Erik F Hauck; Markus Schwefer; Werner Wittkowski; Hans W Bothe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Spine     Volume:  11     ISSN:  1547-5654     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-22     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101223545     Medline TA:  J Neurosurg Spine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-63     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. erikhauck@gmx.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Autonomic Pathways / anatomy & histology,  physiology
Body Weights and Measures
Cadaver
Female
Humans
Lumbosacral Plexus / anatomy & histology*,  physiology*
Male
Microdissection
Nerve Fibers / physiology*,  ultrastructure*
Spinal Nerve Roots / physiology*,  ultrastructure*
Urinary Bladder / innervation
Comments/Corrections
Comment In:
J Neurosurg Spine. 2009 Sep;11(3):253-4; discussion 254   [PMID:  19769505 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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