Document Detail


Measurements of glutathione S-transferase B1 in plasma after birth asphyxia: an early indication of hepatocellular damage.
MedLine Citation:
PMID:  2731373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of glutathione S-transferase (glutathione transferase; EC 2.5.1.18) B1 and B2 subunits (B1 and B2) and activity of alanine aminotransferase (ALT; EC 2.6.1.2) were measured in sequential plasma samples taken from 14 infants with birth asphyxia. Within 6 h of asphyxia, abnormal concentrations of B1 were found in 11 infants, whereas only seven infants showed abnormal ALT activities at this time. In plasma sampled 24 h after birth, values for ALT were abnormal in 10, whereas values for B1 were abnormal in six. Abnormal concentrations of B2 were found in relatively few of these infants, apparently because this monomer is poorly expressed in liver samples obtained up to 41 weeks after conception. We conclude that measurement of B1 may provide a useful index of hepatic impairment in birth-asphyxiated infants.
Authors:
G J Beckett; A J Hussey; I Laing; A F Howie; J D Hayes; R C Strange; C G Faulder; R Hume
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry     Volume:  35     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-21     Completed Date:  1989-07-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  995-9     Citation Subset:  IM    
Affiliation:
University Department of Clinical Chemistry, Royal Infirmary, Edinburgh, Scotland, U.K.
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MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / complications,  enzymology*
Chromatography, Ion Exchange
Clinical Enzyme Tests
Cytosol / enzymology
Glutathione Transferase / blood*
Humans
Infant, Newborn
Isoenzymes / blood
Liver / enzymology
Liver Diseases / diagnosis*,  etiology
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.5.1.18/Glutathione Transferase

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