Document Detail


Measurements of the effects of decellularization on viscoelastic properties of tissues in ovine, baboon, and human heart valves.
MedLine Citation:
PMID:  21919799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the development of tissue-engineered heart valves based on allograft decellularized extracellular matrix scaffolds, the material properties of the implant should be ideally comparable to the native semilunar valves. This investigation of the viscoelastic properties of the three functional aortic/pulmonary valve tissues (leaflets, sinus wall, and great vessel wall) was undertaken to establish normative values for fresh samples of human valves and to compare these properties after various steps in creating scaffolds for subsequent bioreactor-based seeding protocols. Torsional wave methods were used to measure the viscoelastic properties. Since preclinical surgical implant validation studies require relevant animal models, the tests reported here also include results for three pairs of both ovine and baboon aortic and pulmonary valves. For human aortic valves, four cryopreserved valves were compared with four decellularized scaffolds. Because of organ and heart valve transplant scarcity for pulmonary valves, only three cryopreserved and two decellularized pulmonary valves were tested. Leaflets are relatively soft. Loss angles are similar for all tissue samples. Regardless of species, the decellularization process used in this study has little effect on viscoelastic properties.
Authors:
Tong Jiao; Rodney J Clifton; Gabriel L Converse; Richard A Hopkins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-26
Journal Detail:
Title:  Tissue engineering. Part A     Volume:  18     ISSN:  1937-335X     ISO Abbreviation:  Tissue Eng Part A     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-05-16     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101466659     Medline TA:  Tissue Eng Part A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-31     Citation Subset:  IM    
Affiliation:
School of Engineering, Brown University, Providence, Rhode Island 02912, USA. tong_jiao@brown.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Cryopreservation
Elastic Modulus
Elasticity / physiology*
Heart Valves / physiology*
Humans
Middle Aged
Papio / physiology*
Pulmonary Valve / physiology
Sheep, Domestic / physiology*
Tissue Engineering / methods*
Torsion, Mechanical
Viscosity
Young Adult
Grant Support
ID/Acronym/Agency:
P51 RR013986/RR/NCRR NIH HHS; P51RR013986-11/RR/NCRR NIH HHS
Comments/Corrections

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