Document Detail


Measurement of vitamin D in foods and nutritional supplements by liquid chromatography/tandem mass spectrometry.
MedLine Citation:
PMID:  19916369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D is a fat-soluble vitamin with great nutritional interest. An HPLC/MS/MS method was developed to measure vitamin D with atmospheric pressure chemical ionization. Under the experimental parameters used, the LOQ was 0.018 IU/g or 0.45 ng/g, which greatly enhances the capability of measurement of vitamin D at low levels in foods and supplements. This method was validated with spike recovery of 100 +/- 15% and the RSD of less than 10% for most sample matrixes, including infant formula, cheese, cereal and cereal-based foods, multivitamin supplements, and pet foods. The results for vitamin D were compared with those obtained by other methods.
Authors:
Min Huang; Paul LaLuzerne; Doug Winters; Darryl Sullivan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of AOAC International     Volume:  92     ISSN:  1060-3271     ISO Abbreviation:  J AOAC Int     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-11-17     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215446     Medline TA:  J AOAC Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1327-35     Citation Subset:  IM    
Affiliation:
Covance Laboratories Inc., 3301 Kinsman Blvd, Madison, WI 53704, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calibration
Cereals
Cheese
Cholecalciferol / analysis
Chromatography, High Pressure Liquid
Chromatography, Liquid / methods*
Dietary Supplements
Ergocalciferols / analysis
Food Analysis / methods*
Humans
Reproducibility of Results
Tandem Mass Spectrometry / methods*
Vitamin D / analysis*
Vitamins / chemistry
Chemical
Reg. No./Substance:
0/Ergocalciferols; 0/Vitamins; 1406-16-2/Vitamin D; 67-97-0/Cholecalciferol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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