| Measurement of the vascularity and vascular leakage of gliomas by double-echo dynamic magnetic resonance imaging: a preliminary study. | |
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MedLine Citation:
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PMID: 12352166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVE: To evaluate the vascularity and vascular leakage of well-enhanced gliomas by double-echo dynamic magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight patients with glioblastoma multiforme (GBM) and two patients with juvenile pilocytic astrocytoma (JPA) were studied. Double-echo dynamic MR imaging was utilized to separate the T2* shortening effect and the T1 shortening effect. The former was represented by the vascularity index, and the latter was represented by the leakage index. These indexes were compared with histopathologic data. RESULTS: The mean vascularity index of the GBM was higher than that of the JPA (mean +/- SD, 3.48 +/- 1.57 [GBM] versus 0.51 +/- 0.29 [JPA]), and the mean leakage index of the JPA was higher than that of the GBM (1.35 +/- 0.87 [JPA] versus 0.27 +/- 0.15 [GBM]). Abundant vascularity was noted in the tight interstitial space in the pathologic specimen of GBM. Conversely, sparse vasculature was observed in the wide interstitial space in the pathologic specimen of JPA. CONCLUSION: This method may enable better characterization of grade in well-enhanced glioma by providing the information on the vascularity and leakage indexes. |
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Authors:
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Hidemasa Uematsu; Masayuki Maeda; Norihiro Sadato; Yoshiyuki Ishimori; Tsuyoshi Matsuda; Yoshio Koshimoto; Hirohiko Kimura; Hiroki Yamada; Yasutaka Kawamura; Hiroaki Takeuchi; Yoshiharu Yonekura; Harumi Itoh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 37 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-27 Completed Date: 2002-12-19 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 571-6 Citation Subset: IM |
Affiliation:
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Department of Radiology, Fukui Medical University, Fukui, Japan. uematsu@oasis.rad.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Astrocytoma / blood supply*, pathology Brain Brain Neoplasms / blood supply*, pathology Contrast Media Echo-Planar Imaging / methods* Female Gadolinium DTPA / diagnostic use Glioblastoma / blood supply*, pathology Humans Male Middle Aged Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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