Document Detail

Measurement of uterine radiation exposure from lymphoscintigraphy indicates safety of sentinel lymph node biopsy during pregnancy.
MedLine Citation:
PMID:  19267158     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is an increased incidence of breast cancer occurring during pregnancy. Controversy exists as to the safety of performing lymphoscintigraphy during pregnancy and no studies have reported the measured dose of uterine radiation. METHODS: We performed an institutional review board (IRB)-approved prospective study of uterine radiation resulting from lymphoscintigraphy. Abdominal, perineal, and urinary radiation was measured in 14 breast cancer patients and total uterine dose was calculated. RESULTS: The average dose of 99m-Tc sulfur colloid was 39 +/- 20 MBq (1.04 +/- 0.53 mCi). Measured abdominal and pelvic radiation exposure demonstrated no correlation with patient age or body mass index. The average abdominal radiation exposure was 1.17 +/- 0.87 microGy. The average perineal radiation exposure was 0.23 +/- 0.17 microGy. The average dose to the uterus from bladder radioactivity determined from voided urine was 0.44 +/- 0.44 microGy. The average radiation dose to the uterus (average of abdominal and perineal doses plus contribution from bladder dose) was 1.14 +/- 0.76 microGy. One patient was 16 weeks pregnant at the time of sentinel lymph node biopsy (SLNB) and total calculated uterine dose was 1.67 microGy, suggesting that pregnancy does not significantly alter measured uterine radiation. These data were compared with the average background radiation, which is 3,000 microGy per year or 8.2 microGy per day. CONCLUSIONS: The measured uterine dose of radiation from lymphoscintigraphy for SLNB was significantly less than the average daily background radiation. We conclude that lymphoscintigraphy does not expose the fetus to significant radiation and concern of radiation exposure should not preclude the use of SLNB during pregnancy.
Philip M Spanheimer; Michael M Graham; Sonia L Sugg; Carol E H Scott-Conner; Ronald J Weigel
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Publication Detail:
Type:  Journal Article     Date:  2009-03-07
Journal Detail:
Title:  Annals of surgical oncology     Volume:  16     ISSN:  1534-4681     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1143-7     Citation Subset:  IM    
Department of Surgery, University of Iowa, Iowa City, IA, USA.
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MeSH Terms
Breast Neoplasms / pathology*
Middle Aged
Pregnancy Complications, Neoplastic / pathology*
Prospective Studies
Radiation Dosage*
Radionuclide Imaging / methods
Sentinel Lymph Node Biopsy*

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