Document Detail

Measurement of urinary iodine excretion to reveal iodine excess in neonatal transient hypothyroidism.
MedLine Citation:
PMID:  9829229     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to confirm the importance of iodine excess in neonatal transient hypothyroidism. In 30 transient hypothyroid newborns at screening we measured urinary iodine excretion and TSH. They were divided into two groups: group A consisted of 21 newborns who had been exposed to iodine; group B of 9 non-exposed newborns. The two groups were significantly different only for median urinary iodine excretion (p = 0.001). In 61.5% of newborns of group A, iodine exposure caused iodine excess (urinary iodine excretion higher than 185 micrograms/l); this correlated with a higher prevalence of prematurity and a lower mean gestational age. Clinical records should reveal iodine exposure, but only urinary iodine excretion shows iodine excess. We suggest that evaluation at birth of urinary iodine excretion in every newborn with high TSH could help in predicting a good prognosis, since hypothyroidism due to the Wolff-Chaikoff effect is always spontaneously reversible, even if treatment may be suggested.
G Bona; E Chiorboli; A Rapa; G Weber; M C Vigone; G Chiumello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  11     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  739-43     Citation Subset:  IM    
Department of Medical Sciences, University of Torino, Novara, Italy.
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MeSH Terms
Hypothyroidism / blood,  urine*
Infant, Newborn
Infant, Premature / urine
Iodine / urine*
Reference Values
Thyrotropin / blood
Reg. No./Substance:
7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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