Document Detail

Measurement of total bodywater volume with deuterated water in newborn infants.
MedLine Citation:
PMID:  1420609     Owner:  NLM     Status:  MEDLINE    
D2O and H2(18)O are often used as tracers for the determination of total body water (TBW). For newborn infants, the commonly used noninvasive method has not been validated. In this study TBW was calculated from D2O concentrations in blood and compared with TBW calculated from D2O concentrations in urine. TBW calculated from all urine portions voided at least 6 h after D2O administration on average was 1.0% lower. TBW calculated from only three urine portions voided 6, 12, and 24 h after D2O administration was 0.6% (mean) lower compared to TBW calculated from D2O concentrations in blood. This study indicates that the noninvasive method to measure TBW can be considered a reliable method when used in newborn infants.
R Baarsma; P Hof; W G Zijlstra; J P Zock; A Okken
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  62     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-08     Completed Date:  1992-12-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  IM    
Department of Pediatrics, University Hospital Groningen, The Netherlands.
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MeSH Terms
Body Water / metabolism*
Infant, Newborn / metabolism*,  urine
Osmolar Concentration
Reg. No./Substance:

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