| Measurement of tissue perfusion by oxygen transport patterns in experimental shock and in high-risk surgical patients. | |
| | |
MedLine Citation:
|
PMID: 2289979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Survivors of high-risk general (noncardiac) surgery were observed to have cardiac index (CI) values averaging 4.5 l/min.m2, oxygen delivery (DO2) of greater than 600 ml/min.m2, and oxygen consumption (VO2) of 170 ml/min.m2. In contrast, these values were relatively normal in patients who subsequently died. A very early predictive index based on these observations was found to predict outcome in 94% of high-risk patients. The hypotheses that increased DO2 and VO2 in the survivors represent compensatory physiologic responses and that these values were appropriate therapeutic goals were tested in prospective randomized clinical trials and found to reduce mortality and morbidity significantly. The optimal goals were more easily attained with colloids, red cells, dobutamine, and vasodilators, according to their capacity to improve tissue perfusion, as reflected by increased flow and oxygen transport. The extremely complex interactions between DO2 and VO2 are reviewed. |
| | |
Authors:
|
W C Shoemaker; P L Appel; H B Kram |
Related Documents
:
|
8338039 - Resting metabolic rate measured after subjects spent the night at home vs at a clinic. 3370399 - Treadmill protocols for determination of maximum oxygen uptake in runners. 16540709 - Exercise training in normobaric hypoxia in endurance runners. i. improvement in aerobic... 6816129 - Anaerobic threshold for long-term exercise and maximal exercise performance. 1563059 - Amrinone before termination of cardiopulmonary bypass: haemodynamic variables and oxyge... 1602599 - Changes in oxygen uptake-work rate relationship as a compensatory mechanism in patients... 22604889 - Muscle metabolic status and acid-base balance during 10-s work:5-s recovery intermitten... 3842139 - Masking effects on formant frequency structure variability under selected speaking cond... 10758809 - Exercise and hypertension. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Review |
Journal Detail:
|
Title: Intensive care medicine Volume: 16 Suppl 2 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1990 |
Date Detail:
|
Created Date: 1991-04-03 Completed Date: 1991-04-03 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: S135-44 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Martin Luther King, Jr. Hospital Charles R. Drew University, UCLA School of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiac Output Disease Models, Animal Dogs Female Humans Male Middle Aged Oxygen / blood* Oxygen Consumption* Prospective Studies Risk Factors Shock / metabolism*, physiopathology, therapy Surgical Procedures, Operative* |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Localization of two calcium binding proteins, calbindin (28 kD) and parvalbumin (12 kD), in the vert...
Next Document: The relationship between oxygen demand, oxygen uptake, and oxygen supply.