Document Detail

Measurement of tissue oxygen with a fluorescent probe.
MedLine Citation:
PMID:  985408     Owner:  NLM     Status:  MEDLINE    
Evidence is presented that pyrenebutyric acid is nontoxic at the concentrations required for the measurement of fluorescence quenching by physiological concentrations of oxygen. It appears that this molecule can be used to measure tissue oxygen since it does not interfere with oxygen consumption. Equally, tissue components do not interfere with the quenching of fluorescence to such an extent as to invalidate the method. The spatial resolution of the technique is limited by some tissue geometrical factors which do not, however, appear to be great enough to prevent its use to measure intercapillary oxygen gradients.
I S Longmuir; J A Knopp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology     Volume:  41     ISSN:  0021-8987     ISO Abbreviation:  J Appl Physiol     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376576     Medline TA:  J Appl Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  598-602     Citation Subset:  IM    
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MeSH Terms
Butyrates / diagnostic use*,  toxicity
Drug Evaluation, Preclinical
Oxygen Consumption*
Partial Pressure
Pyrenes / diagnostic use*,  toxicity
Reg. No./Substance:
0/Butyrates; 0/Pyrenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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