| Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 9817708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in lung hyperinflation, dyspnea, and exercise endurance are important outcomes in assessing therapeutic responses in chronic obstructive pulmonary disease (COPD). Therefore, we studied the reproducibility of Borg dyspnea ratings, inspiratory capacity (IC; to monitor lung hyperinflation), and endurance time during constant-load symptom-limited cycle exercise in 29 patients with COPD (FEV1 = 40 +/- 2% predicted; mean +/- SEM). Responsiveness was also studied by determining the acute effects of nebulized 500 micrograms ipratropium bromide (IB) or saline placebo (P) on these measurements. During each of four visits conducted over an 8-wk period, spirometry and exercise testing were performed before and 1 h after receiving IB or P (randomized, double-blinded). Highly reproducible measurements included: endurance time (intraclass correlation R = 0.77, p < 0.0001); Borg ratings and IC at rest, at a standardized exercise time (STD), and at peak exercise (R > 0.6, p < 0.0001); and slopes of Borg ratings over time, oxygen consumption (V O2), and ventilation (R > 0.6, p < 0.0001). Responsiveness was confirmed by finding a significant drug effect for: change (Delta) in endurance time (p = 0.0001); DeltaBorgSTD and DeltaBorg-time slopes (p < 0.05); and DeltaIC at rest, at STD, and at peak exercise (p = 0.0001). With all completed visits, DeltaBorgSTD correlated better with DeltaICSTD than any other resting or exercise parameter (n = 115, r = -0.35, p < 0.001). We concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD. |
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Authors:
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D E O'Donnell; M Lam; K A Webb |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 158 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-18 Completed Date: 1998-12-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1557-65 Citation Subset: AIM; IM |
Affiliation:
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Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen's University, Kingston, Ontario, Canada. <odonnell@post.queensu.ca> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bronchodilator Agents / administration & dosage, therapeutic use Cross-Over Studies Double-Blind Method Dyspnea / drug therapy, physiopathology* Exercise Test Female Follow-Up Studies Forced Expiratory Volume / drug effects, physiology Humans Inspiratory Capacity / drug effects, physiology* Ipratropium / administration & dosage, therapeutic use Lung / drug effects, physiopathology* Lung Diseases, Obstructive / drug therapy, physiopathology* Male Middle Aged Nebulizers and Vaporizers Oxygen Consumption / drug effects, physiology Physical Endurance / physiology* Physical Exertion / physiology* Placebos Reproducibility of Results Respiration / drug effects Spirometry Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 0/Placebos; 60205-81-4/Ipratropium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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