| Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects. | |
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MedLine Citation:
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PMID: 16941606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare two methods for assessing the single kidney glomerular filtration rate (SK-GFR) in humans using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS: Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland-Patlak plot and a compartmental model. MR estimates of the SK-GFR were compared with standard radioisotope measures in a total of 75 kidneys. RESULTS: Estimates of renal function using both techniques correlated well with radioisotope-assessed SK-GFR (Spearman's rho=0.81, Rutland-Patlak; rho=0.71, compartmental model). The Rutland-Patlak approach provided a near one-to-one correspondence, while the compartmental method tended to overestimate SK-GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland-Patlak approach. CONCLUSION: DCE-MRI of the kidneys provides data that correlate well with reference measures of SK-GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. |
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Authors:
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David L Buckley; Ala'a E Shurrab; Ching M Cheung; Andrew P Jones; Hari Mamtora; Philip A Kalra |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 24 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1117-23 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Imaging Science and Biomedical Engineering, University of Manchester, Manchester, and Department of Renal Medicine, Hope Hospital, Salford, United Kingdom. david.buckley@manchester.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Algorithms Computer Simulation Contrast Media Female Gadolinium DTPA / diagnostic use*, metabolism, pharmacokinetics Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Kidney / pathology, physiopathology Kidney Diseases / diagnosis*, physiopathology* Kidney Function Tests / methods* Kinetics Magnetic Resonance Imaging / methods* Male Middle Aged Models, Biological* Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
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