Document Detail

Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region.
MedLine Citation:
PMID:  16685258     Owner:  NLM     Status:  MEDLINE    
[Carbonyl-(11)C]WAY-100635 has been used extensively in positron emission tomography (PET) imaging of serotonin 1A receptors (5-HT1A) in vivo in the human brain. Specific binding to receptors is usually estimated using compartmental modeling with arterial plasma input function. The use of reference tissue input (cerebellum) enables quantification without the need of arterial blood sampling, but the accuracy of this method is highly dependent on the validity of the reference region in terms of both specific and nonspecific binding. In this paper, we report exceptionally high uptake of [carbonyl-(11)C]WAY-100635 in the gray matter of cerebellum in one healthy male subject, which was reproducible in repeated PET scanning and most likely represents specific binding to 5-HT1A receptors in cerebellar gray matter. Serotonin 1A receptors are transiently expressed in the human cerebellum during early childhood and usually level off until adolescence but may persist in some individuals. As a methodological implication, the results of this study with regard to test-retest characteristics of [carbonyl-(11)C]WAY-100635 measurements in healthy volunteers using both arterial plasma and reference tissue input functions support the use of cerebellar white matter as reference region, to avoid the potential bias originating from binding of [carbonyl-(11)C]WAY-100635 to 5-HT1A receptors in cerebellar gray matter.
Jussi Hirvonen; Jaana Kajander; Topias Allonen; Vesa Oikonen; Kjell Någren; Jarmo Hietala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-10
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  27     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-95     Citation Subset:  IM    
Department of Psychiatry, University of Turku, Turku, Finland.
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MeSH Terms
Carbon Radioisotopes
Cerebellum / metabolism*,  radionuclide imaging*
Functional Laterality / physiology
Image Processing, Computer-Assisted
Least-Squares Analysis
Linear Models
Magnetic Resonance Imaging
Piperazines / diagnostic use*
Positron-Emission Tomography
Pyridines / diagnostic use*
Radiopharmaceuticals / diagnostic use*
Receptor, Serotonin, 5-HT1A / metabolism*
Reproducibility of Results
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Piperazines; 0/Pyridines; 0/Radiopharmaceuticals; 0/desmethyl-WAY 100635; 112692-38-3/Receptor, Serotonin, 5-HT1A

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