| Measurement of resistance to flow across antroduodenal area during fasting. | |
| | |
MedLine Citation:
|
PMID: 3717339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Changes in antroduodenal resistance to flow may participate in the regulation of gastric emptying and duodenogastric reflux. Little is known, however, about the relationship between antroduodenal resistance and the physiological patterns of contractile activity in this area. We have developed an instrument that maintains an electronically regulated constant-pressure gradient of 2 mmHg across both ends of a flaccid cylinder positioned fluoroscopically across the pylorus. Because resistance bears a constant inverse relationship to flow at a fixed pressure gradient, changes in the recorded rate of airflow through the cylinder are a measure of antroduodenal resistance. In vitro studies showed that, under these conditions, airflow was a function of the diameter and length of the air path and the frequency and duration of external pressure waves greater than 2 mmHg. In vivo studies in four dogs examined the relationship between interdigestive phases of motor activity and variations in resistance exerted by the antroduodenal area. We found that flow rates varied markedly with each phase. Antroduodenal resistance was lowest during motor quiescence (phase I), rose gradually during irregular activity (phase II), and reached its peak during maximal contractile activity (phase III) (P less than 0.05). Resistance was similar for antegrade and retrograde flow. Additional studies suggested that the pyloric area contributes mostly to resistance during phase I, whereas duodenal resistance at least matches that of the pylorus during phase III. |
| | |
Authors:
|
F Mearin; F Azpiroz; J R Malagelada |
Related Documents
:
|
18502739 - Systemic pressure does not directly affect pressure gradient and valve area estimates i... 17605609 - Methods and reliability of echocardiographic assessment of left atrial size and mechani... 17328269 - Disparity between adjusted and actual opening cerebrospinal fluid pressure in a patient... 8241699 - Isolated diastolic dysfunction of the myocardium and its response to coq10 treatment. 1179999 - Ketamine-pancuronium induction in patients with aortic stenosis. 7198519 - Mechanism of early systolic closure of the aortic valve in discrete membranous subaorti... 1082699 - Latent myocardial contractile impairment in patients with angina pectoris. 20224559 - Decreased lung function is associated with increased arterial stiffness as measured by ... 18161009 - Increased pressure stimulates aberrant dendritic cell maturation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 250 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1986 Jun |
Date Detail:
|
Created Date: 1986-07-23 Completed Date: 1986-07-23 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G773-80 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Air Animals Dogs Duodenum / physiology* Fasting* Female Gastric Emptying Gastrointestinal Motility* Models, Biological Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ion transport by neonatal rabbit distal colon.
Next Document: Blood flow limitation of stimulated gastric acid secretion in the rat.