| Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia. | |
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MedLine Citation:
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PMID: 20685053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relative cerebral blood volume (CBV) was estimated using a mild hypoxic challenge in humans, combined with BOLD contrast gradient-echo imaging at 3 T. Subjects breathed 16% inspired oxygen, eliciting mild arterial desaturation. The fractional BOLD signal change induced by mild hypoxia is expected to be proportional to CBV under conditions in which there are negligible changes in cerebral perfusion. By comparing the regional BOLD signal changes arising with the transition between normoxia and mild hypoxia, we calculated CBV ratios of 1.5 ± 0.2 (mean ± S.D.) for cortical gray matter to white matter and 1.0 ± 0.3 for cortical gray matter to deep gray matter. |
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Authors:
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Richard G Wise; Kyle T S Pattinson; Daniel P Bulte; Richard Rogers; Irene Tracey; Paul M Matthews; Peter Jezzard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-04 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 28 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1129-34 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, University of Oxford, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia* Blood Volume Brain / pathology Brain Mapping / methods Cerebral Cortex Cerebrovascular Circulation* Female Humans Magnetic Resonance Imaging / methods* Male Oxygen / chemistry* Perfusion Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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