Document Detail

Measurement of regional cerebrovascular haemoglobin oxygen saturation in cats using optical spectroscopy.
MedLine Citation:
PMID:  1675450     Owner:  NLM     Status:  MEDLINE    
We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percentage haemoglobin: oxygen saturation--is quantified. This saturation is the weighted summation of saturation in the cerebrovascular system: arterial, venous, and capillary beds. In a cat model of progressive cerebral hypoxia, a positive linear correlation between this regional measurement of cerebral saturation and actual saturation, calculated from cerebral arterial and mixed venous blood, was noted (n = 20, r = 0.88, p less than 0.01). The spectroscopic measurement rSHbO2 is also used to index cerebral oxygen extraction. During hypoxia spectroscopic indexed oxygen extraction (iOE) and cerebral arterial-venous difference in oxygen content were simultaneously measured. A least-squares positive linear correlation between these two parameters was noted [AVDO2 = iOE (0.05) + 4.4] (n = 40, r = 0.6, s = 1.2). Objective measurement of 'regional cerebrovascular haemoglobin saturation' and an index of cerebral oxygen extraction are possible using optical spectroscopy.
P W McCormick; M Stewart; P Ray; G Lewis; M Dujovny; J I Ausman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  13     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-07-17     Completed Date:  1991-07-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Henry Ford Neurosurgical Institute, Henry Ford Hospital, Detroit, MI 48202.
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MeSH Terms
Brain Chemistry*
Brain Mapping
Cerebrovascular Circulation*
Oxygen / blood
Oxygen Consumption
Oxyhemoglobins / analysis*
Spectrophotometry, Infrared*
Reg. No./Substance:
0/Oxyhemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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