Document Detail

Measurement of pulse wave velocity using pulse wave Doppler ultrasound: comparison with arterial tonometry.
MedLine Citation:
PMID:  18031922     Owner:  NLM     Status:  MEDLINE    
Pulse wave velocity (PWV), the speed of propagation of arterial pressure waves through the arterial tree, is related to arterial stiffness and is an important prognostic marker for cardiovascular events. In clinical practice PWV is commonly determined by arterial tonometry, with a noninvasive pressure sensor applied sequentially over carotid and femoral arteries. The electrocardiogram (ECG) is used as a timing reference to determine the time delay or "transit time" between the upstroke of carotid and femoral pulse waveforms. Commercially available vascular ultrasound scanners provide a pulsed wave (PW) Doppler velocity signal, which should allow determination of carotid-femoral transit time and hence PWV. We compared carotid-femoral PWV measured by tonometry and by PW Doppler ultrasound (Seimens, Apsen scanner with 7 MHz linear transducer) in asymptomatic subjects (n = 62, 26 male, aged 21 to 72 y). To test for intra-subject and inter-observer variation, ten subjects were scanned by one observer on two occasions 2 wk apart and by two observers on same day. PWV by tonometry ranged from 5.3 to 15.0 m/s. There was no significant difference between mean values of PWV obtained by the two techniques (mean difference: 0.3 m/s, standard deviation of difference: 1.5 m/s), which were closely correlated (r = 0.83). The coefficient of variation for repeated measures on the same subject by the same observer was 10.1% and the inter-observer coefficient of variation was 5.8%. These results suggest a commercial ultrasound scanner can be used to measure PWV, giving results that are reproducible and closely correlated with those obtained by arterial tonometry. (E-mail:
Benyu Jiang; Baoming Liu; Karen L McNeill; Philip J Chowienczyk
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-11-26
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  34     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
King's College of London, Cardiovascular Division, Thomas's Hospital, London, UK.
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MeSH Terms
Blood Flow Velocity
Cardiovascular Diseases / ultrasonography*
Carotid Arteries / physiopathology*
Femoral Artery / physiopathology*
Manometry / instrumentation,  methods
Middle Aged
Observer Variation
Pulsatile Flow
Sensitivity and Specificity
Ultrasonography, Doppler, Pulsed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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