Document Detail

Measurement properties of the six-minute walk test in individuals with exercise-induced pulmonary arterial hypertension.
MedLine Citation:
PMID:  21470356     Owner:  NLM     Status:  Publisher    
Background: Exercise-induced pulmonary arterial hypertension (EIPAH) is associated with reduced peak exercise cardiac output (CO) and aerobic capacity (peak O(2) ). We investigated the validity of the encouraged six-minute walk test (6MWT) to identify exercise limitation and estimate aerobic capacity in subjects with EIPAH. Methods: Seventeen subjects with EIPAH (56 ± 14 years, 15 females) and 20 healthy controls (57 ± 13 years, 19 females) underwent two encouraged 6MWTs and a symptom-limited cardiopulmonary exercise test (CPET). To measure central haemodynamics, subjects with EIPAH performed the CPET with a pulmonary artery catheter in situ. Results: Compared with controls, subjects with EIPAH had reduced peak O(2) (1.2 ± 0.4 vs 1.7 ± 0.5, L/min, P < 0.01), six-minute walk distance (6MWD) (575 ± 86 vs 669 ± 76m, P < 0.001) and six-minute walk work (6MWW) (39 ± 11 vs 45 ± 7, P < 0.01). In subjects with EIPAH, there was a moderate correlation between 6MWD and peak O(2) (r= 0.72, P < 0.01) and a strong correlation between 6MWW and peak O(2) (r= 0.86, P < 0.001). There were significant correlations between 6MWD and peak CO (r= 0.59, P < 0.05), and between peak O(2) and peak CO (r= 0.55, P < 0.05). Peak heart rate was similar in the CPET and 6MWT in subjects with EIPAH (133 ± 15 vs 133 ± 19 beats/minute, P= 0.8). Conclusions: The encouraged 6MWT identifies reduced exercise capacity and provides a valid estimate of aerobic capacity in EIPAH.
Robin M Fowler; Sue C Jenkins; Andrew J Maiorana; Kevin R Gain; Gerry O'Driscoll; Eli Gabbay
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-6
Journal Detail:
Title:  Internal medicine journal     Volume:  -     ISSN:  1445-5994     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Sydney South West Area Health Service. Journal compilation © 2011 Royal Australasian College of Physicians.
Advanced Lung Disease Program, Royal Perth Hospital, Perth, Western Australia; School of Physiotherapy and Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia. Lung Institute of Western Australia (LIWA), Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Western Australia. Advanced Heart Failure and Cardiac Transplant Service, Royal Perth Hospital; Perth, Western Australia. Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, Western Australia. Respiratory Medicine Department, Royal Perth Hospital, Perth, Western Australia. School of Medicine, University of Western Australia, Perth, Western Australia. School of Medicine, University of Notre Dame, Perth, Western Australia. Heart and Lung Transplant Foundation of Western Australia, Perth, Western Australia.
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