| Measurement of plasma prostaglandins during exercise-induced bronchospasm. | |
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MedLine Citation:
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PMID: 977865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bronchospasm following exercise is a phenomenon which occurs in most patients with reversible airway disease. The pathophysiologic mechanism leading to this bronchoconstriction with exercise has not yet been defined. Recently, prostaglandins have been implicated in the etiology of asthma. The purpose of this investigation was to determine changes in plasma prostaglandins occurring during exercise-induced asthma. Eight ambulant asthmatics were chosen for baseline pulmonary spirometry and peripheral venous blood prostaglandin E and F levels. The asthmatics were then exercised to 80% of their age-predicted maximal heart rate via a multistage branching treadmill protocol. At 5, 15, and 30 min following exercise, pulmonary spirometry was again performed and peripheral venous blood collected at the indicated times. Clinical bronchospasm as characterized by audible wheezing and greater than 15% decrease in FEV1 and MMEFR was obtained in all of the asthmatics. Peripheral PGE and PGF2alpha determinations following this exercise protocol were not altered significantly: (PGE: 0 min, 238; 5 min, 185; 15 min, 248; 30 min, 256 pg/ml); (PGF2alpha: 0 min, 50; 5 min, 24; 15 min, 25; 30 min, 17 pg/ml) (p less than 0.1). In summary, no significant change in peripheral blood prostaglandin E and F2alpha levels as determined by radioimmunoassay was noted at the time of exercise-induced bronchospasm. |
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Authors:
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J Field; J Allergra; J Trautlein; L Demers; M Gillin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 58 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1977-01-03 Completed Date: 1977-01-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 581-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchial Spasm
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blood,
etiology* Forced Expiratory Volume Heart Rate Humans Maximal Expiratory Flow Rate Physical Exertion* Prostaglandins E / blood* Prostaglandins F / blood* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 0/Prostaglandins F |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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