Document Detail

Measurement of plasma homovanillic acid concentrations in schizophrenic patients.
MedLine Citation:
PMID:  2193315     Owner:  NLM     Status:  MEDLINE    
1. Several lines of evidence suggest that abnormalities of central dopaminergic transmission may be involved in the expression of some schizophrenic symptoms. However, elucidation of the role of dopamine (DA) in schizophrenia has eluded investigative efforts partially because no accurate and easily repeatable measure of brain DA activity exists. 2. The development of a technique to measure homovanillic acid in plasma has offered the possibility of performing serial measurements of this major DA metabolite. 3. Assuming that plasma homovanillic acid (PHVA) concentrations is an index of brain DA activity, measurement of PHVA can play a role in elucidating the DA abnormality in schizophrenia. 4. Results to date suggest that plasma homovanillic acid concentrations are lower in chronic schizophrenic patients compared to normal controls, and that PHVA values correlate with schizophrenic symptom severity. 5. In addition, PHVA levels were shown to initially rise and subsequently decline during chronic neuroleptic administration in treatment responsive but not in treatment refractory schizophrenic patients.
R Kaminski; P Powchick; P A Warne; M Goldstein; R T McQueeney; M Davidson
Related Documents :
2190545 - Free amino acid levels in oral fluids of normal subjects and patients with periodontal ...
9288865 - Errors in the selection of dialysate concentrates cause severe metabolic acidosis durin...
678465 - Acid hydrolases in blister fluid. 4. influence of ultraviolet radiation.
8399335 - Purification and characterization of a phospholipase a2 from human ileal mucosa.
25213465 - Ursolic acid isolated from the seed of cornus officinalis ameliorates colitis in mice b...
2280185 - Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxo...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  14     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-27     Completed Date:  1990-07-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  271-87     Citation Subset:  IM    
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood*
Circadian Rhythm
Homovanillic Acid / blood*
Physical Exertion
Schizophrenia / blood*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cutaneous odontogenic sinus simulating a basal cell carcinoma: case report and literature review.
Next Document:  The neurochemistry of mania: a hypothesis of etiology and rationale for treatment.