Document Detail


Measurement of plasma homovanillic acid concentrations in schizophrenic patients.
MedLine Citation:
PMID:  2193315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Several lines of evidence suggest that abnormalities of central dopaminergic transmission may be involved in the expression of some schizophrenic symptoms. However, elucidation of the role of dopamine (DA) in schizophrenia has eluded investigative efforts partially because no accurate and easily repeatable measure of brain DA activity exists. 2. The development of a technique to measure homovanillic acid in plasma has offered the possibility of performing serial measurements of this major DA metabolite. 3. Assuming that plasma homovanillic acid (PHVA) concentrations is an index of brain DA activity, measurement of PHVA can play a role in elucidating the DA abnormality in schizophrenia. 4. Results to date suggest that plasma homovanillic acid concentrations are lower in chronic schizophrenic patients compared to normal controls, and that PHVA values correlate with schizophrenic symptom severity. 5. In addition, PHVA levels were shown to initially rise and subsequently decline during chronic neuroleptic administration in treatment responsive but not in treatment refractory schizophrenic patients.
Authors:
R Kaminski; P Powchick; P A Warne; M Goldstein; R T McQueeney; M Davidson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  14     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-27     Completed Date:  1990-07-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  271-87     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood*
Circadian Rhythm
Diet
Homovanillic Acid / blood*
Humans
Physical Exertion
Schizophrenia / blood*,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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