Document Detail

Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method.
MedLine Citation:
PMID:  21314804     Owner:  NLM     Status:  MEDLINE    
AIM: We aimed to measure the levels of total antioxidant status (TAS) in placental samples from preeclamptic pregnant women and evaluate the relation of placental TAS, total oxidant status (TOS) and oxidative stress index (OSI) with fetomaternal compartments using the more recently designated Erel method.
MATERIAL AND METHODS: Thirty four preeclamptic and 27 normotensive pregnant women were enrolled in this prospective controlled study. Subjects were selected from women attending the Obstetrics and Gynecology Department of Gaziantep University. TAS, TOS, OSI were measured from placental, maternal and cord blood samples using a novel automated method. Statistical analyses were performed with SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA).
RESULTS: The TAS level of the placenta was evaluated as significantly lower (P<0.001) in preeclamptic women compared to normotensive women. In preeclamptic pregnancies, while the placental TAS level was not correlated with placental TOS level, the TAS levels of maternal plasma (P<0.001; r=0.584) and cord plasma (P<0.005; r=0.529) were significantly correlated with the TOS level of the placenta.
CONCLUSION: Our results support the concept that placental defective response to an oxidant stimulus plays a central role in the etiopathogenesis of preeclampsia by using the novel automated Erel method.
Ebru Ozturk; Ozcan Balat; Yurdanur Gurcay Acılmıs; Caglayan Ozcan; Sadrettin Pence; Özcan Erel
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Publication Detail:
Type:  Journal Article     Date:  2011-02-11
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  37     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-10-24     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.
Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, Turkey.
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MeSH Terms
Antioxidants / metabolism*
Oxidative Stress
Placenta / metabolism*
Pre-Eclampsia / etiology,  metabolism*
Prospective Studies
Young Adult
Reg. No./Substance:

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