Document Detail

Measurement of placental alkaline phosphatase activity in benign and malignant pleural effusions.
MedLine Citation:
PMID:  1479040     Owner:  NLM     Status:  MEDLINE    
The usefulness of placental alkaline phosphatase (PLAP) as a diagnostic marker of malignancy was assessed in pleural fluid from 60 patients with effusions. Pleural fluid PLAP activities were measured by an enzyme linked immunoassay (ELISA) using the two monoclonal antibodies H17E2 and H317. Similar values were found in groups of patients with primary bronchial tumours (n = 12), secondary malignancies (n = 23), and "benign" conditions (n = 25). The highest values were found in a small subgroup of patients with metastatic ovarian carcinoma. However, the production of this enzyme by normal lung makes the measurement of PLAP in pleural fluid unhelpful as a diagnostic aid to distinguish "benign" from malignant effusions.
R J Fergusson; J Fisken; M A McIntyre; J E Roulston; R C Leonard
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  45     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1114-5     Citation Subset:  AIM; IM    
Department of Clinical Oncology, Western General Hospital, Edinburgh.
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MeSH Terms
Alkaline Phosphatase / analysis*
Antibodies, Monoclonal
Clinical Enzyme Tests*
Enzyme-Linked Immunosorbent Assay
Isoenzymes / analysis*
Pleural Effusion, Malignant / diagnosis*
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Isoenzymes; 0/Tumor Markers, Biological; 0/germ-cell AP isoenzyme; EC Phosphatase

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