Document Detail

Measurement of pituitary hormones: clinical applications. 5. Prolactin.
MedLine Citation:
PMID:  9604     Owner:  NLM     Status:  MEDLINE    
A sensitive and specific assay for human prolactin has been developed using human prolactin and antiserum distributed by the United States National Pituitary Agency. Plasma prolactin concentrations in control subjects ranged from 0-20 ng/ml. No sex difference in prolactin concentration was observed. A brisk increase in plasma prolactin levels occurred in normal subjects during the administration of chlorpromazine and thyroid stimulating hormone releasing factor (TRH). These stimulatory tests of prolactin release should therefore be useful in the assessment of hypothalamic pituitary function. Basal plasma prolactin values were raised in most patients who were being treated with phenothiazines and were helpful diagnostically in patients with amenorrhoea, galactorrhoea, hypogonadism, cranio-pharyngioma, "non-functioning" pituitary tumours and acromegaly. In many of these disorders a significant reduction in the plasma prolactin concentration was observed following oral administration of bromocriptine. Plasma prolactin determinations should be useful in evaluating the response to medical treatment or pituitary ablation.
R A Donald; E A Espiner; S C Hodgkinson; K Evans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New Zealand medical journal     Volume:  83     ISSN:  0028-8446     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
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MeSH Terms
Acromegaly / blood
Antipsychotic Agents / pharmacology
Bromocriptine / pharmacology
Chlorpromazine / pharmacology
Craniopharyngioma / blood
Depression, Chemical
Galactorrhea / blood
Middle Aged
Pituitary Diseases / blood
Prolactin / blood*
Stimulation, Chemical
Thyrotropin-Releasing Hormone / pharmacology
Reg. No./Substance:
0/Antipsychotic Agents; 24305-27-9/Thyrotropin-Releasing Hormone; 25614-03-3/Bromocriptine; 50-53-3/Chlorpromazine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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