| Measurement of phosphorothioate oligodeoxynucleotide antisense transport across the blood-brain barrier. | |
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MedLine Citation:
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PMID: 21922419 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Phosphorothioate oligodeoxynucleotides (PODNs) can act as antisense molecules, knocking down proteins. Many PODNs have the unusual characteristic of being transported across the blood-brain barrier by a saturable system. This means that PODNs injected intravenously can accumulate in the central nervous system in quantities sufficient to knock down proteins in brain and the blood-brain barrier. A critical step in the development of PODNs that can be administered peripherally and knockdown proteins in the central nervous system is to determine the relation to the blood-brain barrier, specifically, does the PODN cross the blood-brain barrier and, if so, how fast and to what degree. |
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Authors:
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William A Banks |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 789 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 337-42 Citation Subset: IM |
Affiliation:
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Geriatrics Research, Education, and Clinical Center, Puget Sound Health Care System, Seattle, WA, USA, wabanks1@u.washington.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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