Document Detail


Measurement of pharyngeal cross-sectional area by finite element analysis.
MedLine Citation:
PMID:  16150845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A noninvasive measurement of pharyngeal cross-sectional area (CSA) during sleep would be advantageous for research studies. We hypothesized that CSA could be calculated from the measured pharyngeal pressure and flow by finite element analysis (FEA). The retropalatal airway was visualized by using a fiber-optic scope to obtain the measured CSA (mCSA). Flow was measured with a pneumotachometer, and pharyngeal pressure was measured with a pressure catheter at the palatal rim. FEA was performed as follows: by using a three-dimensional image of the upper airway, a mesh of finite elements was created. Specialized software was used to allow the simultaneous calculation of velocity and area for each element by using the measured pressure and flow. In the development phase, 677 simultaneous measurements of CSA, pressure, and flow from one subject during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep were entered into the software to determine a series of equations, based on the continuity and momentum equations, that could calculate the CSA (cCSA). In the validation phase, the final equations were used to calculate the CSA from 1,767 simultaneous measurements of pressure and flow obtained during wakefulness, NREM, and REM sleep from 14 subjects. In both phases, mCSA and cCSA were compared by Bland-Altman analysis. For development breaths, the mean difference between mCSA and cCSA was 0.0 mm2 (95% CI, -0.1, 0.1 mm2). For NREM validation breaths, the mean difference between mCSA and cCSA was 1.1 mm2 (95% CI 1.3, 1.5 mm2). Pharyngeal CSA can be accurately calculated from measured pharyngeal pressure and flow by FEA.
Authors:
Khaled F Mansour; James A Rowley; M Safwan Badr
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Publication Detail:
Type:  Journal Article     Date:  2005-09-08
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  100     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-16     Completed Date:  2006-02-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  294-303     Citation Subset:  IM    
Affiliation:
Sleep Research Laboratory, John D. Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
Anatomy, Cross-Sectional / methods*
Computer Simulation
Diagnosis, Computer-Assisted / methods*
Finite Element Analysis
Humans
Manometry / methods*
Models, Biological*
Pharynx / anatomy & histology*,  physiology*
Retrospective Studies
Rheology / methods*
Sleep / physiology
Sleep, REM / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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