| Measurement of peripheral oxygen utilisation in neonates using near infrared spectroscopy: comparison between arterial and venous occlusion methods. | |
| | |
MedLine Citation:
|
PMID: 10742611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to develop an arterial occlusion method and compare it with the venous occlusion method for measurement of peripheral oxygen utilisation in neonates using near infrared spectroscopy (NIRS). Twenty healthy neonates were studied. Arterial occlusion was produced by inflating a neonatal blood pressure cuff to 100 mmHg for 30-40 s and oxygen utilisation (VO(2)) was calculated using the HbO(2) decrement slope following occlusion. Venous occlusion was produced by inflating the cuff to 30 mmHg for 15-20 s and VO(2) was calculated by: VO(2)=HbTx4x(SaO(2)-SvO(2)), where SaO(2) is the arterial oxygen saturation measured by pulse oximetry and SvO(2) is the venous oxygen saturation measured by NIRS. Each baby had a minimum of three arterial and three venous occlusions. Criteria were developed for acceptance/rejection of an occlusion. Using the arterial method, the mean VO(2) was 1.12 mM cm(-1) O(2)/min (S.D.=0.25), (95% CI=1.00-1.24 mM cm(-1) O(2)/min). The coefficient of variation was 6.6+/-4.1%. Using the venous method, the mean VO(2) was 1.60 mM cm(-1) O(2)/min (S.D.=0.48), (95% CI=1. 38-1.82 mM cm(-1) O(2)/min). The coefficient of variation was 12. 6+/-5.7%. The correlation between the two methods was weak (r=0.28 and r(2) was 0.08). The mean difference between the two methods was 0. 47 mM cm(-1) O(2)/min (S.D.=0.51). The limits of agreement were -0. 53 to 1.47 mM cm(-1) O(2)/min. The arterial method gives more consistent results. |
| | |
Authors:
|
I A Hassan; S A Spencer; Y A Wickramasinghe; K S Palmer |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Early human development Volume: 57 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-06-08 Completed Date: 2000-06-08 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 211-24 Citation Subset: IM |
Affiliation:
|
Neonatology Unit, City General Hospital, Stoke on Trent, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arm
/
blood supply* Arteries Female Hemoglobins / analysis Humans Infant, Newborn / metabolism* Male Oxygen Consumption / physiology* Pilot Projects Regression Analysis Reproducibility of Results Spectroscopy, Near-Infrared / methods* Veins |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence of endothelium involvement in the pathophysiology of hydrops fetalis?
Next Document: High frequency ventilation trial. Nine year follow up of lung function.