| Measurement of patients' bivalirudin plasma levels by a thrombelastograph ecarin clotting time assay: a comparison to a standard activated clotting time. | |
| | |
MedLine Citation:
|
PMID: 16632802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Standard activated clotting time (ACT) tests have a poor correlation to bivalirudin levels, leading to uncertainty regarding adequate anticoagulation in percutaneous coronary intervention patients. We tested a Thrombelastograph (TEG) ecarin clotting time (ECT) assay for sensitivity to bivalirudin using blood from 80 patients undergoing interventional cardiology procedures with bivalirudin anticoagulation. This was compared to a standard Hemochron ACT assay using diatomaceous earth. With the TEG assay, the direct thrombin activator, ecarin, was used to initiate coagulation and measured as the reaction time. Plasma samples were evaluated for bivalirudin by a chromogenic assay at an independent hematological laboratory. Linear regression of the standard ACT versus bivalirudin level gave an r = 0.306 whereas the TEG ECT gave a much higher r2 = 0.746 (both P < 0.0001). The TEG ECT should prove more useful than the standard ACT for monitoring bivalirudin anticoagulation across the clinically therapeutic range. |
| | |
Authors:
|
Roger C Carroll; Jack J Chavez; Jeffery W Simmons; Carolyn C Snider; Dale C Wortham; Stuart J Bresee; Eli Cohen |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 102 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-04-24 Completed Date: 2006-05-17 Revised Date: 2012-07-11 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
|
Languages: eng Pagination: 1316-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Coagulation
/
physiology* Blood Coagulation Tests / methods Endopeptidases / diagnostic use* Hirudins / diagnostic use* Humans Linear Models Peptide Fragments / diagnostic use* Recombinant Proteins / diagnostic use Thrombelastography / methods* Whole Blood Coagulation Time / methods |
| Chemical | |
Reg. No./Substance:
|
0/Hirudins; 0/Peptide Fragments; 0/Recombinant Proteins; 128270-60-0/bivalirudin; EC 3.4.-/Endopeptidases; EC 3.4.24.-/ecarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute hemodynamic collapse after induction of general anesthesia for emergent pulmonary embolectomy.
Next Document: Small-dose recombinant activated factor VII (NovoSeven) in cardiac surgery.