Document Detail

Measurement of pH and ionic composition of pericellular sites.
MedLine Citation:
PMID:  239420     Owner:  NLM     Status:  MEDLINE    
The development of ion selective microelectrodes has made it possible to measure the normal steady state in the pericellular environment together with ion fluxes in response to physiological or pathological disturbances. Combined intracellular and extracellular measurements indicate that there is a considerable range of ability between various types of cells in the efficiency with which they can tolerate changes in pericellular conditions. Macrophages are extremely tolerant while cells of the cerebral cortex require a very finely controlled local environment. Combination of ion selective probes with microelectrodes which measure substrate and oxygen availability extend the information which can be obtained about ionic composition of cellular environment and the factors which are important in its homostasis.
I A Silver
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  271     ISSN:  0962-8436     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  261-72     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology
Brain Chemistry
Connective Tissue / analysis
Extracellular Space / analysis*
Fluorescent Dyes
Hydrogen-Ion Concentration
Inflammation / metabolism
Membrane Potentials
Oxygen / analysis,  metabolism
Potassium / analysis,  metabolism
Shock / metabolism
Sodium / analysis
Wound Healing
Reg. No./Substance:
0/Fluorescent Dyes; 0/Metals; 7440-09-7/Potassium; 7440-23-5/Sodium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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