Document Detail


Measurement of oxygen partial pressure in the mandibular bone using a polarographic fine needle probe.
MedLine Citation:
PMID:  16185845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, the oxygen partial pressure in the cancellous bone substance of the mandible was measured for the first time with a polarographic fine needle probe. This has so far only been established in soft tissue. The aim was to prove and to test the feasibility in principle of this method of measurement in order to ascertain the normal values for the O2 partial pressure in healthy bone. These values were afterwards compared with the results of measurements in areas of different pathological bone conditions in order to assess the clinical suitability of the method for "mapping" during mandibular resection. Measurements of oxygen partial pressure were made in a total of 42 patients (16 women, 26 men). Of these, 12 patients with clinically normal bones served as a control group. Seventeen patients had osteoradionecrosis following radiation treatment, and 13 patients presented with chronic osteomyelitis of the mandible. All measurements were carried out with a polarographic fine needle probe applied to the cancellous bone substance. The statistical analysis included a comparison of the mean values of the oxygen partial pressures measured. No statistical correlation between oxygen partial pressure and pH and hemoglobin values could be detected. The average oxygen partial pressure in the healthy mandibular bone was 71.4 mmHg. In non-healthy bone, the value fell to an average of 30.6 mmHg (osteoradionecrosis 32.3 mmHg, chronic osteomyelitis of the mandibular bone 28.4 mmHg). Statistically, the differences in the group values ascertained were highly significant (P < 0.005). The data found show that this method can be successfully used to detect poorly perfused bone. The values are reproducible and reflect the clinical situation. In the long term, the method appears to be a suitable diagnostic tool for assessing the oxygen supply in bone in studying various clinical problems related to bone surgery.
Authors:
P Maurer; L Meyer; A W Eckert; M Berginski; J Schubert
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-09-23
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  35     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  D; IM    
Affiliation:
Klinik und Poliklinik für Mund-Kiefer- und Plastische Gesichtschirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06097 Halle, Germany. peter.maurer@medizin.uni.halle.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calibration
Chronic Disease
Equipment Design
Feasibility Studies
Female
Hemoglobins / analysis
Humans
Hydrogen-Ion Concentration
Male
Mandible / metabolism*
Mandibular Diseases / metabolism
Middle Aged
Needles*
Osteomyelitis / metabolism
Osteoradionecrosis / metabolism
Oxygen Consumption / physiology*
Partial Pressure
Polarography / instrumentation*
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Hemoglobins

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