Document Detail

Measurement of neural respiratory drive in patients with COPD.
MedLine Citation:
PMID:  15766905     Owner:  NLM     Status:  MEDLINE    
Assessment of neural respiratory drive may be useful in patients with chronic obstructive pulmonary disease (COPD) for diverse clinical and academic reasons. We hypothesised that the oesophageal diaphragm EMG during CO2 rebreathing and treadmill exercise could be used for this purpose. The oesophageal catheter consisted of nine consecutive recording electrode coils, which formed five pairs of electrodes with an inter-electrode distance 3.2 cm within a recording pair. Each coil was 1cm in length and the gap between adjacent coils was 0.5 mm. Maximal isometric contractions at functional residual capacity (FRC) and maximal voluntary inspirations from FRC to total lung capacity (TLC) were performed. All subjects performed CO2 rebreathing until end-tidal CO2 was approximately 9% or they became intolerably breathless. There was a good linear relationship between peak of root mean square (RMS) of the diaphragm EMG and end-tidal CO2 (r = 0.92 +/- 0.06) during CO2 rebreathing. The method was also shown to be feasible during exercise. It is concluded that the diaphragm EMG recorded from an oesophageal electrode is a useful technique to assess neural respiratory drive in patients with COPD.
Y M Luo; J Moxham
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  146     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-15     Completed Date:  2005-05-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
Guangzhou Medical College, Guangzhou Institute of Respiratory Diseases, 151 Yanjiang Road, Post Code 510120, Guangzhou, China.
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MeSH Terms
Carbon Dioxide / pharmacology
Diaphragm / physiopathology*
Dose-Response Relationship, Drug
Electromyography / methods
Exercise / physiology
Exercise Test / methods
Functional Residual Capacity
Lung Volume Measurements / methods
Maximal Voluntary Ventilation / drug effects,  physiology
Middle Aged
Muscle Contraction / drug effects,  physiology
Pulmonary Disease, Chronic Obstructive / physiopathology*
Respiratory Mechanics / physiology*
Signal Detection, Psychological
Total Lung Capacity / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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