| Measurement of muscle strength with a handheld dynamometer in patients with chronic spinal muscular atrophy. | |
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MedLine Citation:
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PMID: 20411217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure muscle strength in patients with spinal muscular atrophy using a handheld dynamometer as an objective tool to evaluate the progression of disease and the outcome of therapeutic trials. DESIGN: Maximum voluntary isometric contraction was measured in a group of 24 patients aged 5-38 years with types II and III spinal muscular atrophy. Four muscle groups were examined. Data were grouped according to age and sex. Comparison was made between spinal muscular atrophy types; ambulatory vs non-ambulatory, and survival motor neuron (SMN)2 copies. The results were compared with those of a healthy reference population. RESULTS: Muscle strength was much lower in patients with spinal muscular atrophy than in the healthy population. The walkers group yielded higher values than patients who were non-walkers. Knee extensors were the weakest muscles in both groups, regardless of the ability to walk. The greatest differences were found between ambulatory and non-ambulatory patients. Non-walkers type III patients showed lower values, similar to those for type II patients. Patients with 3 and 4 SMN2 copies showed higher strength with respect to those with 2 SMN2 copies, although not statistically significant. CONCLUSION: The handheld dynamometer is a valid tool for measuring muscle strength in patients with spinal muscular atrophy. It can be used to measure disease progression and to evaluate changes in therapeutic trials. |
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Authors:
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Anna Febrer; Natalia Rodriguez; Laura Alias; Eduardo Tizzano |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine Volume: 42 ISSN: 1651-2081 ISO Abbreviation: J Rehabil Med Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088169 Medline TA: J Rehabil Med Country: Sweden |
Other Details:
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Languages: eng Pagination: 228-31 Citation Subset: IM |
Affiliation:
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Service of Physical Medicine and Rehabilitation, University Hospital Sant Joan de Deu, Barcelona, Spain. afebrer@hsjdbcn.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Hand Strength / physiology Humans Isometric Contraction / physiology Muscle Strength / physiology* Muscle Strength Dynamometer Muscular Atrophy, Spinal / diagnosis, physiopathology*, therapy Spinal Muscular Atrophies of Childhood / diagnosis, physiopathology*, therapy Survival of Motor Neuron 2 Protein / genetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Survival of Motor Neuron 2 Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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