| Measurement and modeling of acid dissociation constants of tri-peptides containing Glu, Gly, and His using potentiometry and generalized multiplicative analysis of variance. | |
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MedLine Citation:
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PMID: 23247603 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report pK(a) values with measurement uncertainties for all labile protons of the 27 tri-peptides prepared from the amino acids glutamic acid (E), glycine (G) and histidine (H). Each tri-peptide (GGG, GGE, GGH, …, HHH) was subjected to alkali titration and pK(a) values were calculated from triplicate potentiometric titrations data using HyperQuad 2008 software. A generalized multiplicative analysis of variance (GEMANOVA) of pK(a) values for the most acidic proton gave the optimum model having two terms, an interaction between the end amino acids plus an isolated main effect of the central amino acid. |
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Authors:
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Rima Raffoul Khoury; Gordon J Sutton; D Brynn Hibbert; Diako Ebrahimi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-18 |
Journal Detail:
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Title: Dalton transactions (Cambridge, England : 2003) Volume: - ISSN: 1477-9234 ISO Abbreviation: Dalton Trans Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101176026 Medline TA: Dalton Trans Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Chemistry, The University of New South Wales, Sydney NSW 2052, Australia. b.hibbert@unsw.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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