Document Detail

Measurement of the mechanical compliance of the endolymphatic compartments in the guinea pig.
MedLine Citation:
PMID:  10867280     Owner:  NLM     Status:  MEDLINE    
During injection of artificial endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes. Pressure differences in the order of 10 Pa could reproducibly be measured upon injection of 2-4 microl of artificial endolymph with a rate of 50 nl/s. Injection of larger volumes damaged the endolymphatic system. From the results, values were derived for the compliances of the membranes surrounding scala media and the vestibular part of the endolymphatic system. The shape of the pressure-time curve during and between repetitive injections of fluid could well be described with a two-component model for the endolymphatic system, consisting of two compartments with compliant walls, connected through a flow resistance. With this model, a larger compliance was found for the second compartment (vestibular part of endolymphatic system) than for the first compartment, into which fluid was injected (scala media).
H P Wit; T J Warmerdam; F W Albers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  145     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-09     Completed Date:  2000-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  82-90     Citation Subset:  IM    
Department of Otorhinolaryngology, University Hospital Groningen, P. O. Box 30.001, 9700 RB, Groningen, The Netherlands.
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MeSH Terms
Basilar Membrane / physiology*
Cochlea / physiology
Endolymph / physiology*
Endolymphatic Sac / physiology
Guinea Pigs
Models, Biological

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