| Measurement of liver iron overload: Noninvasive calibration of MRI-R(2) * by magnetic iron detector susceptometer. | |
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MedLine Citation:
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PMID: 22135193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An accurate assessment of body iron accumulation is essential for the diagnosis and therapy of iron overload in diseases such as thalassemia or hemochromatosis. Magnetic iron detector susceptometry and MRI are noninvasive techniques capable of detecting iron overload in the liver. Although the transverse relaxation rate measured by MRI can be correlated with the presence of iron, a calibration step is needed to obtain the liver iron concentration. Magnetic iron detector provides an evaluation of the iron overload in the whole liver. In this article, we describe a retrospective observational study comparing magnetic iron detector and MRI examinations performed on the same group of 97 patients with transfusional or congenital iron overload. A biopsy-free linear calibration to convert the average transverse relaxation rate in iron overload (R(2) = 0.72), or in liver iron concentration evaluated in wet tissue (R(2) = 0.68), is presented. This article also compares liver iron concentrations calculated in dry tissue using MRI and the existing biopsy calibration with liver iron concentrations evaluated in wet tissue by magnetic iron detector to obtain an estimate of the wet-to-dry conversion factor of 6.7 ± 0.8 (95% confidence level). Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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B Gianesin; D Zefiro; M Musso; A Rosa; C Bruzzone; M Balocco; P Carrara; L Bacigalupo; S Banderali; G A Rollandi; M Gambaro; M Marinelli; G L Forni |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-29 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Centro della Microcitemia e delle Anemie Congenite, E. O. Ospedali Galliera, Genova, Italy; Istituto Nazionale di Fisica Nucleare, Genova, Italy. gianesin@ge.infn.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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