Document Detail

Measurement of leukotriene B4 in arterial blood of asthmatic patients during wheezing attacks.
MedLine Citation:
PMID:  2168469     Owner:  NLM     Status:  MEDLINE    
To investigate whether leukotriene B4 is present in the arterial blood of asthmatic patients during wheezing attacks, 20 ml of arterial blood was drawn from the inguinal artery of five patients. Leukotriene B4 was detected in all five individuals, and its identity was confirmed by a combination of high pressure liquid chromatography and radioimmunoassay techniques. The concentration of leukotriene B4 was 48.34 +/- 16.27 pg ml-1 (mean value +/- SE). However, in five control subjects the leukotriene B4 concentration was found to be 9.43 +/- 5.44 pg ml-1. Thus there was a significant difference between the two groups (P less than 0.05). These results suggest that leukotriene B4 may be important in elucidation of the pathogenesis of bronchial asthma.
K Shindo; Y Matsumoto; Y Hirai; M Sumitomo; T Amano; K Miyakawa; M Matsumura; T Mizuno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  228     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-11     Completed Date:  1990-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Asthma / blood*
Chromatography, High Pressure Liquid
Leukotriene B4 / blood*
Respiratory Sounds / physiology*
Reg. No./Substance:
71160-24-2/Leukotriene B4

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