Document Detail

Measurement of knee cartilage thickness using MRI: a reproducibility study in a meniscectomized guinea pig model of osteoarthritis.
MedLine Citation:
PMID:  17708519     Owner:  NLM     Status:  MEDLINE    
The in vivo precision (reproducibility) of quantitative MRI is of particular importance in osteoarthritis (OA) progression of small magnitude and response to therapy. In this study, three-dimensional high-resolution MRI performed at 7 T was used to assess the short-term reproducibility of measurements of mean tibial cartilage thickness in a meniscectomized guinea pig model of OA. MR image acquisition was repeated five times in nine controls (SHAM) and 10 osteoarthritic animals 3 months after meniscectomy (MNX), in vivo. The animals were then killed for histomorphometric assessment and correlation with the MRI-based measurements. Medial tibial cartilage thickness was measured on MR images using semi-automatic dedicated 3D software developed in-house. The reproducibility of measurements of cartilage thickness was assessed by five repeated MRI examinations with a short recovery delay between examinations (48 h). The computed coefficients of variation were 8.9% for the SHAM group and 8.2% for the MNX group. The coefficients of variation were compatible with expected thickness variations between normal and pathological animals. A positive agreement and significant partial correlation (Spearman r' = 0.74; P < 0.01) between the MRI and histomorphometric data was established. Three-dimensional high-resolution MRI is a promising non-invasive research tool for in vivo follow-up. This modality could be used for staging and monitoring therapy response in small-animal models of OA.
R Bolbos; H Benoit-Cattin; J-B Langlois; A Chomel; E Chereul; C Odet; M Janier; P Pastoureau; O Beuf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  NMR in biomedicine     Volume:  21     ISSN:  0952-3480     ISO Abbreviation:  NMR Biomed     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  366-75     Citation Subset:  IM    
Plate-forme ANIMAGE, Université Claude Bernard Lyon I, Rhône-Alpes Genopole, Lyon, France.
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MeSH Terms
Cartilage / pathology*
Disease Models, Animal
Guinea Pigs
Knee Joint / pathology*
Magnetic Resonance Imaging
Menisci, Tibial / pathology,  surgery*
Osteoarthritis / pathology*
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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