| Measurement of inhibin concentrations in men: study of changes after castration and comparison with androgen levels in testicular tissue, spermatic venous blood, and peripheral venous blood. | |
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MedLine Citation:
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PMID: 2318932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured serum inhibin levels in eight untreated patients with prostatic cancer undergoing castration by RIA using an antiserum against 31-kDa bovine follicular fluid inhibin. The inhibin concentrations in testicular tissue and spermatic venous blood were also measured in six of these patients. Serum inhibin levels (mean +/- SD, 377.8 +/- 212.1 U/L), declined rapidly after castration (15 min after, 233 +/- 171.4; 30 min, 224.6 +/- 156.6; 1 h, 181.5 +/- 95.9; 2 h, 174.3 +/- 69.4; 4 h, 122 +/- 6.4; 6 h, less than 120). High concentrations of inhibin were detected in testicular tissue (31,360 +/- 15,180 U/kg), and the levels in spermatic venous blood (3,178.3 +/- 1,386.8 U/L) were approximately 10 times greater than those in peripheral blood (385.5 +/- 233.1 U/L). Testosterone levels were 1,968.2 +/- 992.3 nmol/kg in testicular tissue and approximately 100 times greater in spermatic venous blood (1,631.6 +/- 389.7 nmol/L) than in peripheral blood (18.0 +/- 4.4 nmol/L). These results suggest that circulating inhibin in men mainly originates from testis and that one of the routes of secretion is via the bloodstream. |
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Authors:
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H Ishida; H Tashiro; M Watanabe; N Fujii; H Yoshida; K Imamura; S Minowada; M Shinohara; K Fukutani; Y Aso |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 70 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-10 Completed Date: 1990-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1019-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, Showa University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Androgens / analysis*, blood Humans Inhibins / analysis*, blood Male Orchiectomy* Prostatic Neoplasms / blood, surgery Radioimmunoassay Spermatic Cord / blood supply, metabolism* Testis / metabolism* Testosterone / analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 57285-09-3/Inhibins; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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