| Measurement of indocyanine green dye concentration in the extracorporeal circulation. | |
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MedLine Citation:
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PMID: 16156302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indocyanine green (ICG) is a dye used to measure plasma volume and cardiac output and to assess hepatic function by monitoring the ICG plasma disappearance rate. A method for continuous and noninvasive measurement of ICG plasma concentration (c) in the extracorporeal circulation is presented using technology originally developed for on-line measurement of hematocrit. As expected from the ICG absorption maximum at 805 nm, the presence of ICG in blood leads to a pronounced increase in hematocrit (Hct) measured by optical means. This apparent change in hematocrit (Hct(rel) = Hct/ Hct(b) - 1) relative to the baseline hematocrit (Hct(b), where c = 0) showed a strong linear relationship (Hct(rel) = k.c) with respect to ICG concentration. The dependence of k on baseline hematocrit was best described by an exponential relationship (k = a*e(b*Hctb)). The constants a and b were determined in in vitro experiments using bovine blood. With the information on a and b, and when baseline hematocrit is known and can be assumed to remain constant throughout the observation phase, plasma ICG concentration can be noninvasively and continuously measured in the extracorporeal circulation by using available optical techniques without taking blood samples. This approach greatly simplifies the diagnostic use of ICG, which may be of importance in patients treated with extracorporeal blood purification techniques. |
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Authors:
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Daniel Schneditz; Parit Mekaroonkamol; Bernd Haditsch; Rudolf Stauber |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 51 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-10-25 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 376-8 Citation Subset: IM |
Affiliation:
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Institute of Physiology, Medical University of Graz, Graz, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Coloring Agents / analysis* Densitometry Dye Dilution Technique Extracorporeal Circulation* Hematocrit Humans Indocyanine Green / analysis* Kinetics |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 3599-32-4/Indocyanine Green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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