| Measurement of inclusion complex formation between cyclophane and biological relevant amino acids using electrospray ionization, cold-spray ionization and fast atom bombardment mass spectrometry. | |
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MedLine Citation:
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PMID: 16079542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The investigation of the host-guest complex formations between cyclophane (TGDMAP) (1) as a host and L-acidic amino acids such as L-glutamic acid (Glu) and L-aspartic acid (Asp) as guests was carried out using fast atom bombardment (FAB), electrospray ionization (ESI) and cold-spray ionization (CSI) mass spectrometry (MS). The stability constant (K(s)) values obtained by the three different MS methods almost agreed. However, the complex ion peaks of a novel cyclophane (CPCn) (2) with Glu and Asp were not observed in FAB-MS. Then, these host-guest complex formations by use of CSI-MS and ESI-MS was examined, as the results, these complex ion peaks were observed clearly and the measurement values by the two MS methods are mostly in agreement. It was concluded that ESI-MS and CSI-MS are available for the determination of K(s) value as well as FAB-MS. |
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Authors:
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Koichi Metori; Yoshihisa Sei; Yumiko Kimura; Tomoyuki Ozawa; Kentaro Yamaguchi; Muneharu Miyake |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 53 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-04 Completed Date: 2005-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 1029-33 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Ethers, Cyclic / chemistry* Magnetic Resonance Spectroscopy Piperidines / chemistry* Spectrometry, Mass, Electrospray Ionization / methods* Spectrometry, Mass, Fast Atom Bombardment / methods* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Ethers, Cyclic; 0/Piperidines; 0/cyclophane 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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