Document Detail

Measurement of inclusion complex formation between cyclophane and biological relevant amino acids using electrospray ionization, cold-spray ionization and fast atom bombardment mass spectrometry.
MedLine Citation:
PMID:  16079542     Owner:  NLM     Status:  MEDLINE    
The investigation of the host-guest complex formations between cyclophane (TGDMAP) (1) as a host and L-acidic amino acids such as L-glutamic acid (Glu) and L-aspartic acid (Asp) as guests was carried out using fast atom bombardment (FAB), electrospray ionization (ESI) and cold-spray ionization (CSI) mass spectrometry (MS). The stability constant (K(s)) values obtained by the three different MS methods almost agreed. However, the complex ion peaks of a novel cyclophane (CPCn) (2) with Glu and Asp were not observed in FAB-MS. Then, these host-guest complex formations by use of CSI-MS and ESI-MS was examined, as the results, these complex ion peaks were observed clearly and the measurement values by the two MS methods are mostly in agreement. It was concluded that ESI-MS and CSI-MS are available for the determination of K(s) value as well as FAB-MS.
Koichi Metori; Yoshihisa Sei; Yumiko Kimura; Tomoyuki Ozawa; Kentaro Yamaguchi; Muneharu Miyake
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  53     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-04     Completed Date:  2005-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1029-33     Citation Subset:  IM    
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
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MeSH Terms
Amino Acids / chemistry*
Ethers, Cyclic / chemistry*
Magnetic Resonance Spectroscopy
Piperidines / chemistry*
Spectrometry, Mass, Electrospray Ionization / methods*
Spectrometry, Mass, Fast Atom Bombardment / methods*
Reg. No./Substance:
0/Amino Acids; 0/Ethers, Cyclic; 0/Piperidines; 0/cyclophane 1

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