Document Detail

Measurement of human chorionic gonadotropin during early pregnancy: a comparison of two immunoradiometric assays.
MedLine Citation:
PMID:  2380624     Owner:  NLM     Status:  MEDLINE    
Evidence of implantation following either in vitro fertilization and embryo transfer (IVF-ET) or gamete intrafallopian transfer (GIFT) was obtained by collecting blood on days 10, 12, 14, 16, and 18 after oocyte recovery (day 0), and retrospectively measuring human chorionic gonadotropin (hCG). This was done using immunoradiometric assays for hCG, manufactured either by Serono Diagnostics Ltd. (MAIAclone) or Diagnostics Products Corporation (IRMA-count). The analysis of 63 serum samples by both kits showed a good correlation (r = 0.99) but the Serono (y) method gave values which were consistently greater (y = 1.58x + 4.89) than those of the DPC (x) method. A comparison of the hCG profile of singleton pregnancies measured with either the Serono (n = 33) or DPC (n = 22) kits gave a similar relationship. These results suggest that great care must be taken when comparing results from different laboratories using different kits. Also, consideration must be given to the possible loss of a continuous database should a laboratory change kit.
P L Matson; M C Newman; D Morroll; S A Troup; B A Lieberman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of in vitro fertilization and embryo transfer : IVF     Volume:  7     ISSN:  0740-7769     ISO Abbreviation:  J In Vitro Fert Embryo Transf     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-12     Completed Date:  1990-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412594     Medline TA:  J In Vitro Fert Embryo Transf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  168-71     Citation Subset:  IM    
Regional IVF Unit, St. Mary's Hospital, Manchester, UK.
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MeSH Terms
Chorionic Gonadotropin / blood*
Fertilization in Vitro
Gamete Intrafallopian Transfer
Immunoradiometric Assay / methods*
Pregnancy Trimester, First / metabolism*
Reagent Kits, Diagnostic
Reference Standards
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Reagent Kits, Diagnostic

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