| Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart Study. | |
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MedLine Citation:
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PMID: 22323242 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ObjectiveTo estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET).DesignCross-sectional twin study.SettingGeneral clinical research centre of a university hospital at Atlanta, USA.PatientsA sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins.Main outcome measuresAll twins underwent imaging of MBF with PET (13)NH(3) at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR.ResultsThe basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65).ConclusionsFor the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging. |
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Authors:
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Shaoyong Su; John Votaw; Tracy Faber; Durreshahwar Khan; J Douglas Bremner; Jack Goldberg; Ken Nichols; Andrew Van Tosh; Viola Vaccarino |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: - ISSN: 1468-201X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Georgia Health Sciences University, School of Medicine, Augusta, Georgia, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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